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This impact might clarify instances of constrictive arachnoiditis and sterile meningitis reported after repeated intrathecal TRIAM injection four Nonetheless, we should level out that CSF investigations concerning markers for cell injury, corresponding to neuron-particular enolase, S-one hundred, neurofilament heavy chain, tau protein supplied no convincing evidence of neuronal or SC harm after the intrathecal TRIAM therapy 35 The interplay of substances applied intrathecally with the MHCII molecule and its role for sterile meningitis remains to be additional investigated as different substances with non-crystalline construction may lead to this aspect effect 36 As we didn't examine the results of TRIAM in neuron-SC cocultures concerning myelination, we are able to only postulate that the late effect on myelination shown on day 23 p.i. could be attributed on an improved SC myelination operate.
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